We have successfully shown that it is possible to use UVC pulsed ray to selectively kill tumor cells and allow non-tumor cells to live. Through in-vivo animal and ex-vivo human and animal testing, we show that new treatments in cancer and dental medicine could be made more effective by including an application to tumor cells of UVC pulses covering a continuous spectrum of at least 230nm-270nm.

Active oxygen can be used for various industrial processes such as surface cleaning, modification, sterilization and oxidation, as it has an extremely strong oxidative ability. It is important for industrial processes to control density of the active oxygen precisely. We are aiming to develop a new sterilization system combined with real time surface reaction monitoring. Through applying a quartz crystal microbalance (QCM) method, it is possible to quantify the amount of active oxygen in industrial processes by measuring frequency shifts of the quartz crystal due to the etching of organic thin film deposited onto the quartz crystal.

Lipid rafts which consist of glycolipids can have a function in signal transduction and are involved in the mechanism of molecular target treatment drugs, but a detailed structural analysis has not yet been conducted. The reason for this is that the detergents that dissolve cell membrane, and the lipids that accumulate within the cell, hinder mass spectrometry for glycolipids. We have established a rapid method for detergent and lipid removal from lipid rafts accumulated fraction. We intend to improve elimination efficiency and incorporate this method into an analysis device in the future, with the goal of developing a versatile method.

The goal of our research is to develop a quantitative measurement method of objective pain evaluation in order to develop a painless needle. We evaluated the expression level of pain transmitting Substance P(SP) in terms of expression area at the time a needle punctures mouse skin, and measured the stress indicator salivary α-amylase levels at the time of each injection. As a result, with a needle with an outer diameter ranging between 200 and 400 μm, the proportion between the SP expression area and needle area of contact was found to be 0.05, and for needles with an outer diameter of 100μm, no pain was found to accompany punctures of duration less than 2 minutes.

The focus of our research is on new diagnostic treatments using MRI. MRI can presently be used to diagnose the existence and type of an illness. Our project uses a creative technique to improve the diagnosis stage several-fold, allowing the generating mechanism of an illness to be made clear, and allowing quick medical treatment in adjacent medical facilities based upon the information gleaned from the MRI. To put this in concrete terms, this technique can be applied to the treatment of dementia and other illnesses, and also raises the brand name of Tokai University on a world-wide scale with the creation of a collaborative organization of both therapeutic medicine and engineering research.